It's a happy coincidence that many of South Africa’s highlights lie upon a clearly defined, easily navigable route, a coincidence that makes it a great destination for first-time visitors.
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South Africa
Storms River mouth, Garden Route.
As a first time visitor it’s almost certain you’ll drive the Garden Route section, either to or from the Cape Region.
If the five to six hour drive is too much, there are great places to break the journey.
Once there, you definitely want to base yourself in one place for several days and explore the Garden Route by car: the distances involved are pretty small and there’s no sense unpacking and repacking more than you have to!
At Knysna you might want to take a cruise on the lagoon out to the Featherbed Nature Reserve, whilst slightly north of the Garden Route, but still an easy day trip, are the Cango Caves. This vast cave system offers a standard guided tour, or a longer adventure tour, which is not for the claustrophobic!
A visit to the Crags, beyond Plettenberg Bay, is a good way to spend a day: there are rescue sanctuaries for primates, African birds and elephants where you get intimate interaction with the inhabitants.